Evidence That Plasma Lipoproteins Inhibit the Factor Vila-Tissue Factor Complex by a Different Mechanism Than Extrinsic Pathway Inhibitor
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منابع مشابه
Evidence that plasma lipoproteins inhibit the factor VIIa-tissue factor complex by a different mechanism that extrinsic pathway inhibitor.
Factor VIIa participates in blood clotting by activating factor X and/or factor IX by limited proteolysis. The proteolytic activity of factor VIIa is absolutely dependent on a lipoprotein cofactor designated tissue factor. We have examined the ability of purified preparations of human plasma high density, low density and very low density lipoproteins, as well as apolipoproteins A-I and A-II, to...
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Lipoprotein-associated coagulation inhibitor (LACI) is a plasma-derived protein that inhibits tissue factor (TF)/factor Vlla-induced coagulation in a factor Xa-dependent manner. The roles of endogenous plasma LAC1 and exogenously added LAC1 and heparin, in the regulation of coagulation, initiated via the intrinsic and extrinsic pathways, were studied using the activated partial thromboplastin t...
متن کاملLipoprotein-Associated Coagulation Inhibitor (LACI) Is a Cofactor for Heparin: Synergistic Anticoagulant Action Between LACI and Sulfated Polysaccharides
Lipoprotein-associated coagulation inhibitor (LACI) is a plasma-derived protein that inhibits tissue factor (TF)/factor Vlla-induced coagulation in a factor Xa-dependent manner. The roles of endogenous plasma LAC1 and exogenously added LAC1 and heparin, in the regulation of coagulation, initiated via the intrinsic and extrinsic pathways, were studied using the activated partial thromboplastin t...
متن کاملLipoprotein-Associated Coagulation Inhibitor (LACI) Is a Cofactor for Heparin: Synergistic Anticoagulant Action Between LACI and Sulfated Polysaccharides
Lipoprotein-associated coagulation inhibitor (LACI) is a plasma-derived protein that inhibits tissue factor (TF)/factor Vlla-induced coagulation in a factor Xa-dependent manner. The roles of endogenous plasma LAC1 and exogenously added LAC1 and heparin, in the regulation of coagulation, initiated via the intrinsic and extrinsic pathways, were studied using the activated partial thromboplastin t...
متن کاملHuman Plasma Extrinsic Pathway Inhibitor Activity : It . Plasma Levels in
Plasma or serum extrinsic pathway inhibitor (EPI) activity was measured in 24 patients with disseminated intravascular coagulation (DIC) and in 23 patients with severe hepatocellular disease. EPI was measured as activity in a test sample that inhibitied factor VIla/tissue factor (TF)catalyzed activation of 3H-factor IX (activation peptide release) in the presence of factor X. Of the 24 patients...
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تاریخ انتشار 1987